Streamline CRISPR screening with Dharmacon All-in-one libraries
RT-qPCR analysis is critical to success in knockdown experiments. Learn about how to rapidly troubleshoot your knockdown experiment from the RT-qPCR results.
Learn how antisense oligonucleotides (ASO) are maximizing treatment efficiency and reducing off-target effects in combinatorial therapies.
In this blog post, we share the highlights of our CRISPRmod CRISPR interference (CRISPRi) system, comparing the activity of Dharmacon’s novel CRISPRi construct dCas9-SALL1-SDS3 to dCas9-KRAB.
CRISPRによる全ゲノムスクリーニングを開始しましょう。新しいDharmacon all-in-one CRISPRプラットフォームなら、これまで以上に簡単に実行できます。
Design and order a plasmid DNA donor kit for insertion of a fluorescent marker
Arrayed siRNA screens are a powerful tool to look at very precise perturbations in cellular pathways.
HAP1細胞の概要、その起源、そしてこれらの細胞株でノックアウトを生成する方法について、お客様の研究にどのように役立つかをご紹介します。
T-cell receptors (TCRs) are crucial components of T cell immunity, enabling the detection and subsequent elimination of abnormal, cancerous and infected cells. Dysfunctional T cell receptor signaling can lead to various immune deficiency or autoimmune diseases. In cancer treatment the study and modification of T cell receptor signaling is important for CAR-T cell therapy as well as modulation of the tumor microenvironment (TME). Modulating T cell activation can be important to avoid rejection of organ or stem cell transplants by the immune response.