HAP1細胞の概要、その起源、そしてこれらの細胞株でノックアウトを生成する方法について、お客様の研究にどのように役立つかをご紹介します。
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T-cell receptors (TCRs) are crucial components of T cell immunity, enabling the detection and subsequent elimination of abnormal, cancerous and infected cells. Dysfunctional T cell receptor signaling can lead to various immune deficiency or autoimmune diseases. In cancer treatment the study and modification of T cell receptor signaling is important for CAR-T cell therapy as well as modulation of the tumor microenvironment (TME). Modulating T cell activation can be important to avoid rejection of organ or stem cell transplants by the immune response.
Cancer is often characterized by dysregulation in cellular pathways and the checkpoints which control cell proliferation, growth, differentiation, and apoptosis. Within the genome there are two types of genes which carefully control cell proliferation and cell death, which are often the driving force behind oncogenesis.
3D culturing is a valuable and increasingly popular cell culture technique. This model recapitulates some physiological characteristics of tissues and tumors driven by cell-cell and cell-matrix contacts, circumventing the need for in vivo experiments in some cases.
mTOR （mechanistic Target of Rapamycin）は環境刺激に応答して細胞増殖を制御するシグナル伝達ネットワークの中心であり、細胞および生体の生理学において不可欠な役割を果たしています。
Atlas of Variant Effects Allianceの目標を達成するために、Wellcome Sanger InstituteはRevvityのHAP1 LIG4(-)細胞株を選択しました。
Read about Celonic's decision to partner with Revvity to leverage the CHOSOURCE™ expression platform for all their antibody and complex molecular development and manufacturing.
大腸がん（CRC）は、大腸または直腸の粘膜から始まる異常な細胞増殖です。
A blog article and application note demonstrating the use of Revvity's Pin-point base editing platform with sensitive cell types
The Toll-like receptors (TLRs) are a family of evolutionarily ancient Patten Recognition Receptors (PRRs) that rapidly detect microbial infection and stimulate the production of pro-inflammatory and antiviral cytokines and chemokines, as well as initiating significant metabolic shifts within the cell. Acting as cellular sentinels for infectious threats, signalling downstream of TLRs sets the stage for successful development of adaptive immunity 1.